DIABETES MELLITUS: SYMPTOMS AND LABORATORY FINDINGS
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Diabetes in adults is often so mild that it is detected only by blood and urine tests. Children and adults with insulin-dependent diabetes show many of the symptoms described below.
Because the blood glucose cannot be used by the tissues, the level of sugar in the blood rises (hyperglycemia). After a night’s fast the blood sugar remains above the normal level (70 to 120 mg per 100 ml). If a glucose tolerance test is made the diabetic patient shows a curve that begins at a higher level and stays higher than the curve for a normal person. The curve comes down slowly for the diabetic person, but sharply for the normal person.
When the blood sugar exceeds the renal threshold (180 mg per 100 ml), some sugar is excreted in the urine (glycosuria). To excrete the sugar, water is taken from the tissues. Thus, the patient complains of frequent urination (polyuria) and increased thirst (polydipsia). The appetite is often increased (polyphagia) because the patient is not fully utilizing the food he normally eats.
When the body is unable to use carbohydrate, it oxidizes more and more fat to supply energy. The liver breaks down the fatty acids to ketones (acetone, beta-hydroxybutyric acid, acetoacetic acid). Normally, the ketones are further broken down to yield energy and the end products carbon dioxide and water. However, in diabetes the breakdown of fatty acids is more rapid than the body can care for. Some of the ketones are excreted in the urine (ketonuria, acetonuria). The ketones are acid products. When they accumulate in the blood the pH of the blood is lowered; the patient then has symptoms of acidosis or diabetic coma.
In addition to the symptoms described above, patients often complain of poor healing of cuts and scratches; boils; itching; cold feet; numbness and tingling of the extremities; and blurring of vision. Cardiovascular disease, renal diseases, and blindness are complications in patients who have had diabetes for many years.
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